Buffalo Horns can be sold in stores for money, though the value of the horns can fluctuate, depending on where and when it is sold. Selling the horns at Manzanita Post or Blackwater will fetch a lower price, while selling it outside of West Elizabeth can be more profitable.
Note: prices listed on this page are based upon the player having neutral honor and playing the game on Normal difficulty. If the player has high honor, the selling price will be Increased by 50% everywhere except Thieves' Landing. Low Honor decreases selling price by 50% everywhere except Thieves' Landing. While playing the game on Hardcore difficulty, money is more scarce and the base, neutral honor price of each item will be slightly lower.