|Hold it right there, outlaw!|
This article is littered with spoilers, so I reckon you might ought'a mosey on down the road if you don't want to read any plot details.
–Mother Superior coming to a grim realization.
Red Dead Redemption
Mother Superior plays a small part in the Stranger side-mission "I Know You". She collects money for the poor. A Strange Man sends Marston to either donate or rob her. If Marston donates, the player will have random encounters with other nuns asking Marston for a donation.
Mother Superior can also be found in Las Hermanas doing odd jobs. She can also be seen eating steak in second floor in Las Hermanas church.
John Marston first meets Mother Superior outside Las Hermanas, while she is busy fighting off an Undead, which she ultimately kills with a repeater shot. After the Undead is killed, John and Mother Superior chat, and Mother Superior says that the other nuns are less inclined to kill the Undead and are not as resourceful as John and herself, so she asks John to save them inside Las Hermanas. After John does so, John asks Mother Superior if she knows anything about the plague, and Mother Superior states that if John can find her an Undead that has recently turned, she can find out more about them.
When John brings her an Undead, Mother Superior suspects that it is an evil cause, and she pours Holy Water on the Undead. The man or woman shortly returns to the world of the living, after being briefly bathed in a blue flame, before it returns to its growling. John notes this, to which Mother Superior informs him that spiritual infections are confusing things that no one can ever understand. After some dialogue, Mother Superior asks John to cleanse Sepulcro, and then gives him the Holy Water. When John cleanses the graveyard and returns to Mother Superior, she will state that a woman mentioned to her that all of this may have been caused by Abraham Reyes, so she tells John that he should travel to Escalera. They don't meet again.
Red Dead Redemption
- In the mission, "Get Back in That Hole, Partner", Seth Briars asks John, "Who made you Mother Nature and Mother Superior, all at the same time?"
- John will bow his head as a greeting when encountering her.