The terrain of New Austin resembles aspects of several real-life Southwestern U.S. states. Cholla Springs resembles Arizona's desert with its saguaro cactus, desert scrub, and prickly pears. The scrub desert of Rio Bravo is strongly reminiscent of New Mexico. Gaptooth Ridge is more like Southern California and western Arizona with its tan rocks and Joshua Trees, and Hennigan's Stead is resembles the western parts of Kansas, Oklahoma, central Colorado, and the square part of Texas called the Panhandle Plains, with the Eastern end (Stillwater Creek) resembling the The South comprising of North Texas, East Texas, and Louisiana.
People in MacFarlane's Ranch and in Armadillo will mention Governor Nate Johns, suggesting that New Austin and West Elizabeth are located in the same territory, or are both one single territory. This is further evidenced by the lack of any government building in New Austin, but there are a few in West Elizabeth.
The railroad tunnel between Hennigan's Stead and Cholla Springs and the snow capped canyon in north Hennigan's Stead are some of the few places in the game where the player is, technically, off the map.
MacFarlane's Ranch is the largest settlement in the region, despite its status as a privately owned ranch.
The "racing track" in Gaptooth Ridge is the westernmost point in the game.
As with the boundary between New Austin and West Elizabeth, the transition of the music when the player moves between New Austin and Nuevo Paraiso can take some time to register.